Providing the inspiration for the TV series Columbo, the theatrical predecessor Prescription: Murder tells the story of a brilliant psychiatrist and his mistress who hatch a plot to murder his neurotic, possessive wife. The execution of their plan and the creation of their perfect alibi depends on a bizarre impersonation. Lt. Columbo must engage the psychiatrist in a duel of wits until the doctor succeeds in having Columbo removed from the case. However, it is the mistress who proves to be the weak link that leads to a trap and a surprising climax!